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Long-Term Weight Loss Associated With Pharmacotherapy, Lifestyle Interventions

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A new study presented at ENDO 2022, the annual meeting of the Endocrine Society, found that individuals who were managed with anti-obesity medications experienced an average weight loss of 10.6 per cent over 3 to 5 years. This finding was based on the participant’s ability to maintain the weight loss.

A retrospective observational study was carried out on persons ranging in age from 18 to 75 years by the researchers to identify the link between anti-obesity drugs and the management of weight reduction. In the course of the research, a total of 428 individuals who were either obese or overweight received treatment at a weight management facility between April 2014 and April 2016.

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Chart analysis led to the determination of a beginning and an ending date for the use of anti-obesity medicine that was allowed by the Food and Drug Administration of the United States as well as off-label. The patients’ self-reports served as the basis for calculating their overall exposure to each medicine. The drugs metformin (76.2 per cent), phentermine (31.1 per cent), topiramate (30.8 per cent), bupropion (29.9 per cent), and semaglutide (29.9 per cent) were the ones that were used to treat obesity the most often (24.5 per cent).

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The researchers’ follow-up with each patient averaged out to 4.4 years. Initial body mass indexes averaged 34.3 kg/m2 on average. Patients were classified according to their weight into one of four categories: overweight (19 per cent), class 1 obesity (35 per cent), class 2 obesity (25 per cent), and class 3 obesity (5 per cent) (20 per cent). When analysing the data, the researchers classified weight recovery as higher than 3 per cent of the person’s lowest weight. According to the study’s findings, the median amount of time needed to reach the nadir weight was 1.9 years, with an average change of 10.6 per cent (-10.9 kg) from the initial visit.

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